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Second, improving aging-related metabolic disorders

Normalization of vitamin B12 (B12) levels achieved following 1000 mcg oral Eligen B12 therapy: a clinical study comparing the efficacy and safety of oral B12 therapy versus intramuscular (IM) therapy

Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review with meta-analyses